Low free and bioavailable testosterone levels may predict pathologicallyproven high-risk prostate cancer: a prospective, clinical trial
نویسندگان
چکیده
منابع مشابه
Low circulating free and bioavailable testosterone levels as predictors of high-grade tumors in patients undergoing radical prostatectomy for localized prostate cancer.
OBJECTIVE Controversy exists regarding the propensity of hypogonadism and metabolic disorders to promote the development of high-risk prostate cancer (PCa). Our aim was to prospectively test whether preoperative circulating testosterone levels, obesity, and metabolic syndrome (MetS) were correlated with aggressive pathological features after radical prostatectomy (RP). MATERIAL AND METHODS Ov...
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At the present, many drugs are used for inhibition of uterine contractions, but the proportions of preterm labors are increasing. Although magnesium sulfate is the most commonly prescribed parenteral tocolytic agent, but its optimal use has yet to be delineated. In this study a high-dose protocol for magnesium sulfate tocolytic therapy was compared with a low-dose regimen. One-hundred patie...
متن کاملDetermined Free Serum Testosterone is Better than Total Testosterone as a Predictor of Prostate Cancer Risk
Background: Circulating testosterone remains the main source of androgens, however only 1%-2% circulates as free testosterone (fT), hormone active form. To compare the performance of serum fT and total testosterone (tT) as predictors of prostate cancer (PCa) detection and aggressiveness. Methods: Serum fT (RIA, pg/mL) and tT (LC/MS, ng/dL) were prospectively determined in 3364 consecutive men w...
متن کاملHigh-grade prostate cancer is associated with low serum testosterone levels.
BACKGROUND The aim of this study was to assess whether low serum testosterone levels in men with newly diagnosed prostate cancer have an association to the endocrine status, prostate-specific antigen (PSA) levels, Gleason score, and androgen receptor expression. METHODS Besides a full clinical work-up, the following hormones were quantified in men with newly diagnosed prostate cancer by serum...
متن کاملLow free testosterone levels in rheumatoid arthritis.
The androgen status of 25 male patients with rheumatoid arthritis (RA) was assessed and compared with that of age matched controls with osteoarthritis (OA). Significantly reduced levels of serum free testosterone were found in the RA group. Within that group free testosterone was unrelated to all indices of disease activity measured, though it was strongly related to latex positivity. These res...
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ژورنال
عنوان ژورنال: Türk Üroloji Dergisi/Turkish Journal of Urology
سال: 2017
ISSN: 2149-3235,2149-3057
DOI: 10.5152/tud.2017.35467